PCDDB

PCDDB archives circular dichroism (CD) and synchrotron radiation CD (SRCD) spectral data together with associated experimental metadata to provide validated, curated datasets for analysis of protein structure and dynamics.

Key Features:

• Data validation and curation: Each entry undergoes validation and curation to ensure completeness, consistency, and quality of spectral information.
• Spectral data formats: Spectral data are provided as graphical displays and as downloadable text files.
• Database integration: Entries are linked to primary sequence and structural databases (UniProt, PDB) and to secondary classification databases (Enzyme Commission, CATH).
• Literature citations: Each dataset includes associated literature citations to document experimental provenance.

Scientific Applications:

• Protein structure and dynamics: Provide validated CD and SRCD spectra to support studies of protein secondary structure and conformational dynamics.
• Protein folding: Facilitate investigation of protein folding by making curated spectral datasets available for comparison and analysis.
• Protein function and interactions: Enable exploration of protein function and interactions by linking spectral data to sequence and structural annotations.

Methodology:

Validation and curation of entries; archiving of CD and SRCD spectral data with associated experimental metadata; linking entries to UniProt, PDB, Enzyme Commission and CATH; and inclusion of literature citations.