PDB_Graph_API

PDB_Graph_API provides RESTful programmatic access to macromolecular structural data and associated functional and biophysical annotations from the Protein Data Bank (PDB) and integrated knowledge-graph resources for computational analysis.

Key Features:

• Extensive Data Access: Exposes over 80 RESTful endpoints to retrieve detailed information from the Protein Data Bank (PDB) and related annotations.
• Integration with Major Databases: Incorporates updated data and cross-references from UniProt, Pfam, CATH, SCOP and PDBe-KB partner resources.
• Regular Updates: Data and annotations are distributed via weekly releases to include the latest structural information.

Scientific Applications:

• Structural Biology Research: Enables retrieval and analysis of macromolecular structural details to support studies of function and molecular interactions.
• Bioinformatics Analysis: Supports integration of diverse structural and annotation datasets for computational analyses and annotation workflows.
• Drug Discovery and Development: Provides structural annotations and cross-references useful for rational drug design and target identification.

Methodology:

Implements a RESTful API on top of an integrative graph database architecture using Neo4J, enabling efficient querying and traversal of relationships between interconnected biological entities for retrieval of structural and annotation data.