PeCoP

PeCoP predicts positional conservation in protein sequences to identify amino acid residues likely important for protein structure and function.

Key Features:

• Iterative PSI-BLAST Integration: Uses iterative PSI-BLAST (Position-Specific Iterated BLAST) searches to gather homologous sequences.
• Family Member Collation: Collates close and distant family members across species to assemble a diverse dataset for conservation assessment.
• Positional Conservation Analysis: Analyzes assembled sequence alignments to identify positions conserved across evolutionary distances.

Scientific Applications:

• Protein Structure Prediction: Identifying conserved regions to guide three-dimensional structure models.
• Functional Annotation: Suggesting functional importance of residues to aid annotation of uncharacterized proteins.
• Drug Target Identification: Highlighting conserved residues that may serve as potential therapeutic targets.

Methodology:

Collate homologous sequences using iterative PSI-BLAST searches across species and evolutionary distances, then perform positional conservation analysis on the assembled sequences to determine conserved positions.