PepQueryMHC

PepQueryMHC integrates MHC-bound peptide sequences with translated RNA-seq reads for rapid and comprehensive tumor antigen prioritization.

Key Features:

• Class I and II antigen prioritization: PepQueryMHC enables efficient prioritization of both class I and class II tumor antigens.
• Cellular origin mapping: PepQueryMHC maps the cellular origins of presented peptides.
• Proteasome-spliced peptide analysis: PepQueryMHC resolves uncertainties surrounding the prevalence of proteasome-spliced peptides.
• Non-reference sequence support: PepQueryMHC addresses current method limitations with non-reference sequences.

Scientific Applications:

• Tumor antigen prioritization: PepQueryMHC prioritizes tumor-specific MHC-bound peptides for cancer immunotherapy development.
• Immunopeptidomics data analysis: PepQueryMHC analyzes immunopeptidomics data to determine tumor-specificity of presented peptides.
• Cancer immunotherapy development: PepQueryMHC supports the identification of targets for cancer immunotherapy by determining tumor-specificity of MHC-bound peptides.

Methodology:

PepQueryMHC integrates MHC-bound peptide sequences with translated RNA-seq reads.