PepTherDia

PepTherDia provides a curated database and analytical resource for structural composition analysis and annotation of approved peptide therapeutics and diagnostics to support peptide drug discovery.

Key Features:

• Curated repository: A curated repository of approved peptide drugs and diagnostic agents, comprising over 100 peptides as of 2020.
• Structural composition analysis: Structural composition analyses and detailed annotations of structural features for each compound.
• Physicochemical and pharmacokinetic annotations: Annotated physicochemical properties and pharmacokinetic information for individual peptides.
• Clinical and regulatory annotations: Information on indications, routes of administration, and marketing authorizations associated with each peptide.
• Production and design-origin metadata: Records of production methodologies and origins of design for peptide therapeutics and diagnostics.
• Design-support analyses: Analytical support to inform design and early-stage pre-screening of peptide candidates.

Scientific Applications:

• Peptide drug discovery: Inform structural and physicochemical design decisions for peptide therapeutics and diagnostics.
• Pattern identification: Identify structural and physicochemical patterns associated with approved peptide agents.
• Guideline development: Support establishment of criteria and guidelines aimed at increasing approval rates of future peptide candidates.
• Medicinal chemistry support: Aid medicinal chemists in early-stage selection and pre-screening of peptide candidates.

Methodology:

Curation of approved peptide therapeutics and diagnostics combined with structural composition analyses and compilation of physicochemical, pharmacokinetic, indication, administration route, production methodology, marketing authorization, and design-origin annotations.