PERSEUS
PERSEUS visualizes pedigrees as directed graph networks using a force-repulsion layout to explore genetic relationships among accessions and to trace phenotypic traits to ancestral donors.
Key Features:
- Directed graph pedigree representation: Pedigrees are represented as directed graph networks with nodes corresponding to individuals or accessions.
- Force-repulsion layout: A force-repulsion method is used to distribute nodes in the network for clearer visualization of relationships.
- Trait search and export: Phenotypic traits can be searched along pedigrees and exported for downstream analysis.
- Trait tracing to ancestors: The system supports tracing phenotypic traits back to ancestral donors within the pedigree graph.
- Support for genomic selection and prediction analyses: Visualizations and trait data are provided to aid genomic selection and prediction workflows.
- Applicability to accessions and germplasm collections: Designed to represent and analyze relationships among accessions in breeding programs and germplasm collections.
Scientific Applications:
- Breeding program analysis: Exploration of pedigree relationships and trait inheritance to inform selection decisions in breeding programs.
- Germplasm curation and management: Analysis of lineage and trait provenance within germplasm collections and accession catalogs.
- Evolutionary and genealogy studies: Investigation of genealogical relationships and lineage histories among related individuals or species.
- Genotypic and phenotypic diversity analysis: Assessment of diversity patterns across accessions using pedigree and trait information.
- Trait provenance and donor identification: Identification of ancestral donors contributing specific phenotypic traits.
Methodology:
Pedigrees are represented as directed graph networks with nodes as individuals and laid out using a force-repulsion algorithm; interactive network exploration and trait search/export functionality are provided.
Topics
Details
- Cost:
- Free of charge
- Tool Type:
- web application
- Operating Systems:
- Mac, Linux, Windows
- Programming Languages:
- JavaScript
- Added:
- 5/24/2024
- Last Updated:
- 11/24/2024
Operations
Publications
Pradas N, Jurado-Ruiz F, Onielfa C, Arús P, Aranzana MJ. <i>PERSEUS:</i> an interactive and intuitive web-based tool for pedigree visualization. Bioinformatics. 2024;40(2). doi:10.1093/bioinformatics/btae060. PMID:38310342. PMCID:PMC10898331.
Links
Repository
https://github.com/aranzana-lab/PERSEUS