Peryton

Peryton provides a manually curated database of experimentally supported associations between microorganisms and diseases, containing over 7,900 entries linking 1,396 microorganisms to 43 diseases.

Key Features:

• Manual Curation: Content is compiled from manual curation of biomedical literature with each entry backed by experimental evidence.
• Standardization and Systematization: Diseases and microorganisms are standardized using reference resources to create comprehensive database dictionaries.
• Detailed Annotations: Entries include annotations of experimental design, study cohorts, and techniques employed, specifying high-throughput or low-throughput methods.

Scientific Applications:

• Hypothesis Generation: Aggregates experimentally supported associations to suggest candidate microbe-disease links for further study.
• Cross-validation: Enables comparison and validation of findings against curated experimental evidence.
• Exploration of Microbe-Disease Interactions: Provides a standardized overview of known microorganism–disease associations to support research into disease mechanisms.

Methodology:

Content was compiled by manual curation of biomedical literature and standardized using reference resources to build database dictionaries, with each association supported by reported experimental evidence.