PETAL

PETAL analyzes biological pathways to detect long-distance crosstalk mechanisms and reveal critical nodes and interactions within pathway networks.


Key Features:

  • Long-distance crosstalk detection: Identifies long-distance crosstalk mechanisms within biological pathway networks.
  • Comprehensive pathway analysis: Performs comprehensive analyses to map interactions across pathways.
  • Exhaustive automated search: Automates an exhaustive search within pathways to detect critical nodes and interactions without manual intervention.
  • Implementation: Implemented in Python 3.

Scientific Applications:

  • Therapeutic target and biomarker discovery: Aids in identifying novel therapeutic targets and biomarkers hidden within complex pathway networks.
  • Drug development and disease strategy: Supports identification of pathway-based avenues for drug development and disease treatment strategies.
  • Pathway interaction mapping: Reveals hidden connections and maps pathway interactions relevant to disease mechanisms.

Methodology:

Automates an exhaustive search within pathways to detect critical nodes and interactions; implemented in Python 3.

Topics

Details

Programming Languages:
Python
Added:
1/18/2021
Last Updated:
1/23/2021

Operations

Publications

Sgroi G, Russo G, Pappalardo F. PETAL: a Python tool for deep analysis of biological pathways. Bioinformatics. 2020;36(22-23):5553-5555. doi:10.1093/bioinformatics/btaa1032. PMID:33325491.