pevoSOAR

pevoSOAR identifies and compares similar surface regions on protein three-dimensional structures to predict functional and evolutionary relationships.

Key Features:

• Input Flexibility: Accepts a PDB ID or an uploaded structure file as input for analysis.
• Surface Similarity Detection: Identifies similar surface patterns by comparing local sequence, geometric shape, and spatial orientation of protein surfaces.
• Multiple Search Modes: Provides various search modes to compare proteins based on local sequence similarity, geometric shape, and spatial orientation.
• Statistical Significance: Reports statistically significant matches to support reliability of detected surface similarities.

Scientific Applications:

• Functional Prediction: Predicts biological functions for proteins with known three-dimensional structures but unknown roles.
• Exploration of Functional Relationships: Infers potential functional relationships between proteins by identifying similar surface regions.
• Evolutionary Studies: Aids investigation of evolutionary origins and conservation of structural elements critical to protein function.

Methodology:

pevoSOAR utilizes a geometric approach to define pockets and voids on protein surfaces and compares these features across proteins by evaluating local sequence, geometric shape, and spatial orientation using multiple search modes to identify similarities indicative of functional or evolutionary relationships.