PGV

PGV visualizes reference-agnostic pan-genomes to represent and enable exploration of genes and non-coding sequences across cultivars, accessions, or strains within a species.


Key Features:

  • Reference-Agnostic Representation: Represents pan-genomes without reliance on a single reference genome, capturing genes and non-coding sequences present across individuals.
  • Consensus Ordering: Organizes genomic data using consensus ordering to facilitate comparison and the identification of structural variations.
  • Interactive Visualization: Provides interactive visualization capabilities for exploring pan-genomic variation and relationships among genomes.

Scientific Applications:

  • Comparative Genomics: Enables comparison of genomic content and structure across multiple genomes within a species without a reference.
  • Evolutionary Biology: Supports analysis of genomic diversity and structural variation for evolutionary inference.
  • Plant Breeding and Diversity Studies: Facilitates visualization of pan-genomic variation across cultivars, accessions, or strains to inform studies of genetic diversity.

Methodology:

Implements a reference-agnostic representation of pan-genomes and organizes genomic sequences using consensus ordering for visualization and comparison.

Topics

Details

License:
MIT
Cost:
Free of charge
Tool Type:
command-line tool
Operating Systems:
Mac, Linux, Windows
Programming Languages:
Python
Added:
4/9/2022
Last Updated:
4/9/2022

Operations

Publications

Liang Q, Lonardi S. Reference-agnostic representation and visualization of pan-genomes. BMC Bioinformatics. 2021;22(1). doi:10.1186/s12859-021-04424-w. PMID:34656081. PMCID:PMC8520301.

PMID: 34656081
PMCID: PMC8520301
Funding: - National Science Foundation: IIS-1814359, IOS-1543963