phageReceptor

phageReceptor provides a database compiling 427 high-quality phage-host receptor interactions between 341 viral species or sub-species and 69 bacterial species, with data on receptor types, structural characteristics, and network analyses of phage protein receptors (PPRs).

Key Features:

• Comprehensive Interaction Data: Contains 427 high-quality phage-host receptor interactions covering 341 viral species or sub-species and 69 bacterial species.
• Diversity in Receptor Types: Documents receptor types showing sugars and proteins as predominant receptors with distinct usage patterns between Gram-positive and Gram-negative bacteria, including protein receptors on outer membranes.
• Structural and Functional Characterization: Reports that phage protein receptors (PPRs) have low sequence identity and lack common mammalian virus receptor domains, indicating distinct evolutionary pathways.
• Network Analysis: Performs network analysis of PPRs in Escherichia coli protein-protein interaction networks and reports higher node degrees and betweenness for PPRs compared to other proteins.
• Expression Levels: Includes expression-level comparisons showing PPRs generally exhibit higher expression than other outer membrane, plasma membrane, or intracellular proteins.

Scientific Applications:

• Mechanistic studies: Enables investigation of molecular mechanisms of phage-host interactions.
• Evolutionary comparisons: Supports comparison of viral receptor evolution across organisms.
• Antibacterial strategy development: Informs development of antibacterial strategies targeting phage receptors.
• Resistance research: Aids study of bacterial resistance to phages.

Methodology:

Data were compiled by manual curation of literature and experimental data and analyzed via Escherichia coli protein-protein interaction network analysis using node degree and betweenness metrics.