phagesdb

phagesdb provides comprehensive genomic data and genetic resources for mycobacteriophage research to support analysis of viral diversity, genome architecture, and applications in Mycobacterium genetics.

Key Features:

• Genomic repository: Hosts genomic data for more than 10,000 isolated mycobacteriophages, including over 2,100 completely sequenced genomes.
• Host reference: Includes phages that infect Mycobacterium hosts, notably Mycobacterium smegmatis mc2155.
• Genome architecture and mosaicism: Highlights architectural diversity and mosaic genome organization across mycobacteriophage genomes.
• Unknown gene catalog: Documents numerous genes of unknown function present in mycobacteriophage genomes.
• Genetic tools for Mycobacterium: Provides information on integration-proficient vectors and recombineering systems for delivery of reporter genes, transposons, and allelic exchange substrates into Mycobacterium hosts.
• Support for therapeutic research: Supplies genomic resources used to investigate mycobacteriophages' potential for therapeutic applications against Mycobacterium infections.

Scientific Applications:

• Viral diversity and evolution: Enables comparative genomics and studies of diversity, mosaicism, and evolutionary relationships among mycobacteriophages.
• Mycobacterium genetics: Facilitates development and use of phage-derived vectors and recombineering approaches for genetic manipulation of Mycobacterium.
• Phage therapy research: Supports identification and characterization of candidate phages and genomic determinants relevant to therapeutic development against Mycobacterium infections.
• Education and training: Provides genomic data used in high-school and undergraduate research and education programs.

Methodology:

Provides genomic data for over 10,000 mycobacteriophage isolates, including more than 2,100 complete genome sequences.