PheLiGe

PheLiGe aggregates over 75 billion human genotype-phenotype associations from genome-wide and region-wide association scans, including cis-eQTLs, to enable comparative analysis and causal inference of genetic effects on phenotypes.

Key Features:

• Extensive Database: Houses over 75 billion genotype-phenotype associations sourced from 7,347 genome-wide association scans (GWAS) and 1.2 million region-wide association scans, including cis-eQTLs.
• Comparative Analysis of Regional Association Patterns: Compares regional patterns of association across traits to assess whether co-associations reflect pleiotropy or linkage.
• Integrative Causal Gene Implication: Compares association patterns for complex traits with gene expression and protein levels to help implicate candidate causal genes.

Scientific Applications:

• Functional Genomics: Explore the biological implications of genetic variants by examining their associations across multiple phenotypes.
• Genetic Architecture Studies: Dissect the genetic basis of complex traits by distinguishing pleiotropy from linkage through regional pattern comparisons.
• Causal Inference: Prioritize candidate causal genes by integrating genotype-phenotype associations with gene expression and protein-level data.

Methodology:

Aggregates GWAS and region-wide association scan summary statistics and compares regional genotype-phenotype association patterns across traits and against gene expression and protein-level associations to assess pleiotropy, linkage, and implicate causal genes.