PHENIX

PHENIX automates macromolecular structure determination using X-ray crystallography, neutron diffraction, electron cryo-microscopy, and related methods.

Key Features:

• Automation and Integration: Advanced algorithms reduce manual intervention and integrate computational tasks across data processing, model building, and refinement.
• Experimental Technique Support: Supports X-ray diffraction, neutron diffraction, and electron cryo-microscopy and is tailored to handle method-specific properties of experimental data.
• Structure Solution Workflow: Provides automated steps for initial data-quality assessment, model building, validation, rebuilding, refinement, and deposition.
• Repetitive-task Automation and Defaults: Automates repetitive procedures and applies default parameter settings to promote consistent, objective processing.

Scientific Applications:

• Structural Genomics: Enables high-throughput determination of protein structures from genomic sequences to populate protein structure databases.
• Molecular Mechanism Analysis: Produces macromolecular models used to investigate biological processes at the molecular level.
• Drug Discovery and Therapeutics: Provides accurate macromolecular structures that support structure-based drug design and therapeutic development.

Methodology:

Advanced algorithms perform automated data-quality assessment, model building, validation, rebuilding, refinement, and structure deposition while integrating computational tasks to minimize subjective input.