PhyloPro

PhyloPro performs phylogenetic profiling of user-defined gene subsets across 120 eukaryotic genomes to analyze evolutionary conservation and lineage-specific innovations.

Key Features:

• Extensive Genome Utilization: Leverages a collection of 120 eukaryotic genome sequences to generate comprehensive phylogenetic profiles.
• User-Defined Gene Subsets: Accepts user-specified subsets of genes from model organisms for targeted evolutionary analysis.
• Pathway and Complex Analysis: Analyzes pathways and protein complexes to identify core conserved elements and lineage-specific innovations.
• Visualization of Phylogenetic Profiles: Produces visual representations of phylogenetic profiles to support interpretation of evolutionary trajectories.

Scientific Applications:

• Comparative Evolutionary Studies: Enables comparison of gene presence–absence and conservation patterns across diverse eukaryotic lineages.
• Conserved Element Identification: Facilitates detection of conserved components within biological pathways and complexes.
• Lineage-Specific Innovation Analysis: Supports identification of lineage-specific gene gains, losses, or innovations across eukaryotes.

Methodology:

Integrates genomic data from 120 eukaryotic genomes and applies phylogenetic profiling and visualization to user-defined gene subsets to reveal conserved and divergent evolutionary patterns.