Phylostat

Phylostat analyzes paralogous clade divergence within phylogenetic trees to assess gene duplication and deletion events and their effects on the functional evolution of gene families.

Key Features:

• Statistical Analysis (bootstrapping): Incorporates bootstrapping to evaluate support for gene clustering and the assignment of duplication and deletion events within phylogenetic trees.
• Comparative Clade Divergence Analysis: Performs comparative analyses of paralogous clades to characterize divergence patterns following gene duplication.
• Duplication and Deletion Event Assignment: Identifies and assigns gene duplication and deletion events within phylogenetic trees to aid interpretation of paralog divergence.

Scientific Applications:

• Evolutionary biology and genomics: Provides insights into systematic divergence of paralog clades to inform studies in evolutionary biology and genomics.
• Molecular evolution: Aids identification of functional divergences among paralogous genes within gene families.
• Comparative and functional genomics: Clarifies paralog relationships and divergence patterns to support comparative and functional genomics analyses.

Methodology:

Built on the phylo.io platform; leverages visual and statistical methods, including bootstrapping, to analyze phylogenetic trees and determine clade divergence following gene duplication events.