piano

Piano is a web server that provides information about pseudouridylation, which is a chemical modification found on uridine in RNA molecules. It is known as the fifth RNA nucleotide and has important roles in various biological processes. With the help of high-throughput sequencing technology, thousands of pseudouridylation sites have been discovered in different biological contexts. However, there is still much that is unknown about the distribution, functions, regulation, and disease relevance of this modification.

Topic

Gene transcripts;RNA splicing;Functional, regulatory and non-coding RNA;Epigenetics;RNA-Seq

Detail

  • Operation: PTM site prediction;Data retrieval;Splice site prediction;miRNA target prediction

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Publications

  • Enriching the gene set analysis of genome-wide data by incorporating directionality of gene expression and combining statistical hypotheses and methods.
  • Väremo L, et al. Enriching the gene set analysis of genome-wide data by incorporating directionality of gene expression and combining statistical hypotheses and methods. Enriching the gene set analysis of genome-wide data by incorporating directionality of gene expression and combining statistical hypotheses and methods. 2013; 41:4378-91. doi: 10.1093/nar/gkt111
  • https://doi.org/10.1093/nar/gkt111
  • PMID: 23444143
  • PMC: PMC3632109
  • PIANO: A Web Server for Pseudouridine-Site (Ψ) Identification and Functional Annotation.
  • Song B, et al. PIANO: A Web Server for Pseudouridine-Site (Ψ) Identification and Functional Annotation. PIANO: A Web Server for Pseudouridine-Site (Ψ) Identification and Functional Annotation. 2020; 11:88. doi: 10.3389/fgene.2020.00088
  • https://doi.org/10.3389/FGENE.2020.00088
  • PMID: 32226440
  • PMC: PMC7080813

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