PICMI

PICMI maps amino acid and nucleotide variations onto a reference genome and its gene products to determine affected genes and specific isoforms.

Key Features:

• Comprehensive mapping: Maps one or more amino acid or nucleotide variations directly onto a genome and its gene products and identifies whether these variations affect specific genes and their isoforms.
• Alternative splicing support: Accommodates analysis of alternatively spliced isoforms to determine isoform-specific impacts of variations.

Scientific Applications:

• Molecular biology and genetics: Assess the impact of nucleotide and amino acid variations on gene function and regulation.
• Bioinformatics: Support mapping and analysis of large genomic variation datasets by placing variants in genomic and transcript contexts.
• Clinical research: Investigate how specific variations may influence disease phenotypes or treatment responses.

Methodology:

Integrates user-provided variation data with comprehensive genomic databases and systematically maps variations onto the genome and gene products, including all known isoforms, to identify affected genes and isoform-specific impacts.