Pathway Interaction Database (PID)

Pathway Interaction Database provides curated information on human molecular signaling, regulatory events, and key cellular processes for analysis of molecular interaction networks.

Key Features:

• Curated Pathways: Contains curated and peer-reviewed pathways representing human molecular signaling and regulatory events.
• Search Capabilities: Enables retrieval of predefined pathways and generation of interaction network maps centered on specific molecules or cellular processes.
• Batch Query Tool: Accepts lists of molecules (e.g., from microarray experiments) to overlay on pathways or visualize complete molecular connectivity maps.
• Data Export Options: Provides data export in extensible markup language (XML) and Biological Pathways Exchange (BioPAX) Level 2 formats.

Scientific Applications:

• Cancer research: Supports analysis of signaling networks and regulatory events relevant to oncogenesis and tumor biology.
• Neuroscience: Enables exploration of neuronal signaling pathways and molecular interactions relevant to neural function and disease.
• Developmental biology: Supports investigation of signaling pathways involved in development and differentiation.
• Immunology: Enables analysis of immune signaling and regulatory interactions.
• Pathway-centered omics analysis: Facilitates hypothesis generation, experimental design, and interpretation of pathway-level omics data.

Methodology:

Content consists of curated, peer-reviewed pathways and is updated monthly with new pathway information.