PiMS LIMS

PiMS LIMS manages high-throughput nanolitre-scale protein crystallization trials by linking crystallization trial images and metadata to support protein structure determination.

Key Features:

• Nanolitre-scale crystallization management: Handles nanolitre-scale crystallization experiments conducted in 96-well and higher-density plates.
• Image–metadata linkage: Links crystallization trial images with associated metadata via a database layer for comprehensive data management and retrieval.
• Automated imager support: Supports integration with three automated imagers for high-throughput image acquisition.
• Legacy database compatibility: Provides a mapping layer to interface with legacy databases and enable data integration.
• PiMS standards compliance: Adheres to standards set by the Protein Information Management System (PiMS).

Scientific Applications:

• Protein structure determination: Centralizes crystallization trial data and images to support workflows for protein structure determination.
• Optimization of crystallization conditions: Facilitates optimization of crystallization conditions through tracking and analysis of trial outcomes.
• High-throughput crystallization monitoring: Enables monitoring and management of large-scale crystallization trials at nanolitre scale in 96-well and higher-density plates.

Methodology:

Links visual data from crystallization trials with detailed metadata via a database layer and uses a mapping layer to interface with legacy databases.