PINAWeb

PINAWeb performs comparative alignment and analysis of protein-protein interaction networks (PPINs) to evaluate topological and biological coherence across multiple network aligners.

Key Features:

• Data Input: Accepts PPINs from the STRING database and user-provided datasets for alignment.
• Multiple Aligners Integration: Supports the aligners AligNet, HubAlign, LGraal, Pinalog, and Spinal for network alignment computations.
• Comparative Analysis: Generates reports with topological and biological correctness scores to evaluate and compare alignment methods.
• Alignment Visualization: Visualizes agreements and differences among alignments produced by multiple aligners.

Scientific Applications:

• Protein-Protein Interaction Prediction: Aids prediction and transfer of protein-protein interactions by preserving topological integrity and biological coherence in PPIN alignments.
• Aligner Benchmarking and Selection: Enables comparison of multiple aligners to select methods appropriate for specific research needs.

Methodology:

Implements the algorithms of the supported aligners (AligNet, HubAlign, LGraal, Pinalog, Spinal) to compute network alignments and assesses alignment quality using scoring metrics that evaluate topological and biological correctness.