PINV

PINV visualizes protein-protein interaction (PPI) networks to enable interactive exploration and analysis of multi-organism PPI datasets.

Key Features:

• Interactive visualization: Provides interactive network visualization with dynamic graphic layouts for complex PPI data.
• D3-based rendering: Utilizes the D3 library to generate dynamic graph layouts and visual representations.
• BioJS integration: Implements components that adhere to the BioJS protocol for interoperable visualization modules.
• Querying and filtering: Includes components to query, filter, and manipulate visible subsets of interactions.
• Multi-organism network support: Supports visualization of multi-organism interaction networks including predicted targets from Mycobacterium tuberculosis, interacting partners, and orthologs.
• Database compatibility: Accepts PPI datasets from resources such as the Interologous Interaction Database.

Scientific Applications:

• Network exploration: Visual analysis of complex PPI networks to identify interaction patterns and topology.
• Cross-species and orthology analysis: Examination of interologs and ortholog relationships across organisms within interaction networks.
• Pathogen-target analysis: Investigation of predicted Mycobacterium tuberculosis targets and their interacting partners.

Methodology:

Implements BioJS components and uses the D3 library to produce dynamic graph layouts and provides querying and filtering components for manipulating interaction subsets.