PKconverter

PKconverter converts and computes pharmacokinetic parameters in R to characterize drug absorption, distribution, metabolism, and excretion for population and individual pharmacokinetic analyses.

Key Features:

• R implementation: Provided as an R package for computational pharmacokinetic parameter conversion and calculation.
• Parameter conversion and computation: Calculates various pharmacokinetic parameters based on established functional interrelationships.
• Post‑model derivation: Computes additional parameters that are not directly estimated within a fitted pharmacokinetic model by deriving them from existing estimates.
• Standard error estimation: Calculates standard errors associated with derived pharmacokinetic parameters.
• Population and individual estimation: Supports estimation of both population-level and individual patient-specific pharmacokinetic parameters, including simultaneous estimation of individual parameters.

Scientific Applications:

• Population pharmacokinetic analysis: Enables derivation and reporting of population-level pharmacokinetic parameters from model estimates.
• Individualized parameter estimation: Supports estimation of individual patient-specific parameters for personalized medicine analyses.
• Derived-parameter reporting: Facilitates computation of parameters not directly estimated in models to expand reported pharmacokinetic metrics.
• Uncertainty quantification: Provides standard errors for derived parameters to assess estimation precision.

Methodology:

Implemented as an R package that computes pharmacokinetic parameters from fitted pharmacokinetic model estimates using established functional relationships, calculates standard errors for derived parameters, and supports simultaneous estimation of individual patient-specific parameters.