PLAbDab-nano

PLAbDab-nano provides a searchable repository of approximately 5000 annotated camelid VHH and shark VNAR nanobody sequences curated from patents and academic literature, with links to primary sources.

Key Features:

• Sequence Database: Contains approximately 5000 annotated VHH and VNAR sequences from camelid and shark species.
• Literature and Patent Curation: Sources sequences from both academic literature and patents, with links to primary literature sources.
• Self-updating Repository: Automatically updates to incorporate new nanobody sequences as they become available.
• Sequence Search: Enables users to find sequences similar to known patented or therapeutic entries.
• Library Design Support: Facilitates the design of diverse nanobody libraries.

Scientific Applications:

• Therapeutic Development: Supports identification of VHH and VNAR modalities as promising therapeutic formats due to their small size, solubility, and high thermostability.
• Biological Research: Provides a valuable resource for a wide range of biological applications leveraging nanobody properties.
• Intellectual Property Analysis: Enables comparison of sequences against known patented or therapeutic entries to assess novelty and freedom to operate.
• Library Construction: Aids in the design of diverse nanobody libraries for discovery campaigns.

Methodology:

The sources describe that methods were used to curate entries from patents and literature, but do not provide explicit computational details.