Plant ER UPRome

Plant ER UPRome catalogs ER-to-nucleus unfolded protein response (UPR) signaling components and provides curated annotations across diverse plant species to support research on ER stress–mediated regulation of nuclear gene expression.

Key Features:

• Centralized Database: Compiles peer-reviewed, curated annotations of UPR-associated genes and ER-to-nuclear signaling pathways across diverse plant species to address poor annotation of UPR genes.
• Pathway Viewer: Provides a pathway visualization that encodes relationships and detailed annotations among UPR signaling components and ER sensors.
• Candidate Gene Identification: Enables identification of candidate genes linked to phenotypes associated with ER stress responses through curated pathway and gene annotation data.
• Collaborative Data Contribution: Supports incorporation of contributed gene and experimental data to expand and update the repository.

Scientific Applications:

• UPR and Stress Response Studies: Supports investigation of the role of the UPR in plant adaptive responses to environmental stressors by linking ER sensors to nuclear gene expression changes.
• Signal Transduction Analysis: Facilitates analysis of ER sensor-mediated signal transduction affecting nuclear transcriptional programs.
• Pathway Integration: Enables examination of UPR integration with hormone signaling, immune responses, and developmental pathways.
• Functional Genomics and Phenotype Mapping: Aids identification of candidate genes for experimental validation in studies of plant development, hormone regulation, immunity, and stress management.

Methodology:

The database compiles curated information from ongoing investigations in model plant systems, and the pathway viewer encodes pathway interactions and gene annotations for exploration.