PLATO

PLATO predicts protein targets and bioactivity profiles of small molecules using reverse ligand-based screening to support target fishing in drug discovery.

Key Features:

• Reverse Ligand-Based Screening: Uses known experimentally active compounds to predict potential protein targets and bioactivity profiles of small molecules via reverse screening.
• Efficient Backend Implementation: Implements a backend engineered for rapid processing, delivering results in under 20 seconds.
• PDF Reports: Exports results as portable document format (PDF) reports.
• Validation and Performance: Validated on thousands of external datasets and demonstrated superior performance compared to other parallel approaches.

Scientific Applications:

• Target Fishing: Predicts potential protein targets for small molecules to enable target-fishing studies.
• Bioactivity Profiling: Assesses bioactivity profiles of small molecules to inform compound prioritization.
• Polypharmacology Assessment: Aids understanding of polypharmacological profiles to support identification of promising therapeutic candidates.

Methodology:

Performs reverse ligand-based screening by analyzing a comprehensive collection of experimentally active compounds to predict interactions between small molecules and protein targets based on structural similarities.