pmTR

pmTR provides population-specific germline allelic data for human T-cell receptor loci to enable analysis of allelic frequencies and genetic diversity across the TRA, TRB, TRG, and TRD loci.

Key Features:

• Population-Specific Data: Alleles compiled from approximately 2,500 individuals representing 26 ethnicities across five major superpopulations, enabling population-resolved allele frequency analyses.
• Comprehensive Allelic Inventory: Includes 205 TRAV, 249 TRBV, 16 TRGV, and 5 TRDV germline alleles, each supported by at least four haplotypes.
• African Diversity: Reports the highest germline allelic diversity in African populations relative to non-African groups.
• Asian-Specific Alleles: Identifies a significant subset of TR alleles that are specific to Asian populations.
• Integration with IMGT: Provides population-specific annotations that complement alleles catalogued in the IMGT database.

Scientific Applications:

• Immunogenetics Research: Supports studies of the genetic bases of immune responses, including analyses of vaccination efficacy and disease susceptibility across populations.
• Population Genetics: Enables analysis of how TR germline allele frequencies and diversity vary among ethnicities and superpopulations.
• Vaccine Design Insights: Supplies population-resolved TR allele data to inform considerations of T-cell receptor repertoire variation in vaccine development.

Methodology:

Alleles were identified and organized as true germline alleles with complete TR allele sequences using variant data profiled from the "1,000 Genomes" project.