Polbase

Polbase compiles curated experimental data and literature on DNA polymerases to provide integrated sequence, structural, biochemical, and genetic information linked to source publications and external databases.

Key Features:

• Scope: Comprehensive compilation of DNA polymerases and their associated literature and experimental results.
• Experimental data: Stores detailed experimental results with relevant experimental details and traceability to original source publications.
• External links: Integration with PubMed, UniProt, and the RCSB Protein Data Bank to connect literature, sequence, and structural records.
• Data types: Includes polymerase sequences, structures, and biochemical and genetic property annotations.
• Curation: Curated and validated entries aggregated from contributions by polymerase investigators.
• Interoperability: Supports custom analysis via external software applications.

Scientific Applications:

• Genetics: Facilitate analysis of polymerase genetic properties through curated sequence and literature data.
• Structural biology: Enable sequence–structure correlation using RCSB Protein Data Bank-linked structural records.
• Biochemistry: Support comparison of biochemical properties across polymerases using compiled experimental results.
• Literature validation: Provide traceability of experimental findings back to original publications for result validation and reproducibility.

Methodology:

Compilation and curation of experimental results linked to source publications and integration with PubMed, UniProt, and the RCSB Protein Data Bank.