PolyQ

PolyQ compiles a centralized database of information on polyglutamine (polyQ) diseases to support research into their genetic, proteomic, and clinical characteristics.

Key Features:

• Molecular basis: Documents the role of abnormally expanded CAG triplet repeats in coding regions that produce elongated glutamine tracts in proteins and disrupt cellular functions.
• Disease scope: Covers nine polyQ diseases: Huntington's disease, dentatorubral-pallidoluysian atrophy (DRPLA), spinal and bulbar muscular atrophy (SBMA), and spinocerebellar ataxias SCA1, SCA2, SCA3, SCA6, SCA7, and SCA17.
• Data types: Aggregates information on epidemiology, causative genes, protein characteristics, pathophysiology, and clinical manifestations.
• Centralized compilation: Consolidates fragmented published information into a single database (PolyQ-DB) for integrated reference.
• Update policy: Is continuously updated with new research findings to maintain current coverage of the literature.

Scientific Applications:

• Genetic analysis: Enables study of CAG repeat expansions and causative gene relationships across polyQ diseases.
• Proteopathy investigation: Supports analysis of elongated glutamine tracts and their effects on protein characteristics and cellular processes.
• Epidemiology and clinical phenotype studies: Provides aggregated epidemiological and clinical manifestation data for population and phenotype analyses.
• Comparative disease research: Facilitates cross-disease comparisons among the nine polyQ disorders to investigate shared and distinct mechanisms.

Methodology:

PolyQ-DB compiles information from published research literature and is continuously updated with new findings.