POLYVIEW-2D

POLYVIEW-2D generates two-dimensional graphical representations of protein sequences and structures annotated with secondary structure, relative solvent accessibility, functional motifs, and polymorphic sites to support analysis of protein structure and function.

Key Features:

• Sequence Annotations: Generates annotations of secondary structure, relative solvent accessibility, functional motifs, and polymorphic sites for protein sequences and structures.
• Customizable Visualizations: Produces customizable two-dimensional graphical representations applicable to experimentally determined and predicted protein structures.
• Integration with Prediction Servers: Integrates data from protein structure prediction servers to visualize predicted models alongside experimentally determined structures.
• Automated Generation: Automatically generates annotated image files for downstream analysis and dissemination.
• Input Types: Processes both protein sequences and protein structures as input.

Scientific Applications:

• Protein Structure Analysis: Supports analysis of protein folding and stability by visualizing secondary structure and solvent accessibility annotations.
• Functional Motif Identification: Highlights functional motifs within proteins to support studies of protein function and interactions.
• Evolutionary Studies: Annotates polymorphic sites to support studies of evolutionary conservation and variation.

Methodology:

Processes input protein sequences or structures to compute annotations (secondary structure, relative solvent accessibility, functional motifs, polymorphic sites) and generate two-dimensional annotated visualizations, integrating data from protein structure prediction servers and experimentally determined structures.