prada

prada analyzes high-throughput phenotyping data from cellular assays, including flow cytometry (FACS) and high-content screening microscopy, and integrates these analyses within the Bioconductor R ecosystem for genomic and molecular biology research.


Key Features:

  • Interoperability with Bioconductor: Leverages Bioconductor infrastructure built on the statistical programming language R to access interoperable bioinformatics packages.
  • Extensive Package Ecosystem: Benefits from the Bioconductor repository of 934 contributed packages covering diverse bioinformatic and statistical applications.
  • Rigorous Quality Assurance: Relies on Bioconductor's formal initial review process and continuous automated testing for package reliability.
  • Facilitation of Interdisciplinary Research: Supports interdisciplinary collaboration by integrating methods and packages relevant to multiple scientific domains.
  • Rapid Development Environment: Operates within Bioconductor's open-development model that enables rapid iteration and enhancement of software packages.

Scientific Applications:

  • High-throughput phenotyping experiments: Processes and analyzes large-scale phenotyping datasets from cellular assays.
  • Flow cytometry (FACS) data analysis: Handles FACS-derived measurements for cellular phenotyping and population analysis.
  • High-content screening microscopy analysis: Analyzes high-content imaging data for cellular behavior and morphological profiling.
  • Genomics and molecular biology research: Supports studies of gene expression patterns and molecular interactions within genomics and molecular biology contexts.

Methodology:

Implements computational analysis using the statistical programming language R and integrates with Bioconductor; employs data manipulation, visualization, and interpretation routines and leverages Bioconductor's package review and continuous automated testing infrastructure.

Topics

Collections

Details

License:
GPL-3.0
Tool Type:
command-line tool, library
Operating Systems:
Linux, Windows, Mac
Programming Languages:
R
Added:
1/17/2017
Last Updated:
11/25/2024

Operations

Publications

Huber W, Carey VJ, Gentleman R, Anders S, Carlson M, Carvalho BS, Bravo HC, Davis S, Gatto L, Girke T, Gottardo R, Hahne F, Hansen KD, Irizarry RA, Lawrence M, Love MI, MacDonald J, Obenchain V, Oleś AK, Pagès H, Reyes A, Shannon P, Smyth GK, Tenenbaum D, Waldron L, Morgan M. Orchestrating high-throughput genomic analysis with Bioconductor. Nature Methods. 2015;12(2):115-121. doi:10.1038/nmeth.3252. PMID:25633503. PMCID:PMC4509590.

Documentation

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