PRAWNS

PRAWNS defines metablocks across multiple genomes to enable scalable comparative genomics and large-scale genotype-phenotype association analyses, including linking genomic regions to antibiotic resistance in Acinetobacter baumannii.

Key Features:

• Scalability: Handles large-scale genomic data efficiently, overcoming limitations of tools that struggle beyond tens of genomes.
• Metablock Definition: Introduces "metablocks," concise sets of genomic features used as foundational elements for genome comparison.
• Pairwise Relationships: Identifies pairwise relationships between metablocks to facilitate detailed comparative analyses across multiple genomes.
• Genotype-Phenotype Associations: Enables large-scale genotype-phenotype association studies by leveraging metablocks and their relationships to link genomic variation to phenotypic traits such as antibiotic resistance.

Scientific Applications:

• Antibiotic resistance mapping in Acinetobacter baumannii: Identification of genomic regions associated with antibiotic resistance in Acinetobacter baumannii.

Methodology:

Defines metablocks across multiple genomes and analyzes pairwise relationships to detect patterns and associations relevant to phenotypic traits; implemented in C++ and Python3.