PRES

PRES analyzes functional perturbations associated with adenosine-to-inosine (A-to-I) RNA editing sites to characterize their downstream regulatory, structural, and pathway impacts.

Key Features:

• Editome Profiling: Accepts editome profiles derived from RNA-Seq across sample groups and annotates RNA editing sites with respect to genomic elements.
• Differential Editing Site Detection: Identifies differential A-to-I RNA editing sites across samples using user-selected methods and thresholds.
• Functional Perturbation Characterization: Assesses impacts of differential editing on miRNA and RNA-binding protein regulation, RNA and protein structure modifications, and disrupted biological pathways.
• Gene Prioritization: Ranks genes based on the predicted functional impacts of their associated RNA editing events.
• Annotation Integration: Integrates genomic annotations with RNA editing data to contextualize editing events relative to genes and regulatory elements.

Scientific Applications:

• Regulatory Mechanism Studies: Dissects how A-to-I RNA editing alters miRNA and RBP interactions and RNA/protein structure to affect regulation.
• Disease Mechanism and Progression Analysis: Supports investigation of editing perturbations observed across human diseases to explore their contributions to pathology and progression.
• Biomarker and Target Prioritization: Enables prioritization of genes and editing events as candidate biomarkers or therapeutic targets based on functional impact.

Methodology:

Performs editome profiling, differential RNA editing site detection, and functional perturbation analysis by integrating genomic annotations with computational analyses of RNA editing data.