ProFeatMap

ProFeatMap visualizes protein feature architectures by generating customizable two-dimensional maps of domains, repeats, disordered regions, and post-translational modifications (PTMs) to enable comparative analysis across lists of proteins.

Key Features:

• Customizable 2D Mapping: Generates two-dimensional maps that display protein features such as domains, repeats, disordered regions, and post-translational modifications (PTMs) along sequence coordinates.
• Integration with Established Databases: Retrieves annotated features from UniProt and InterPro.
• User-Defined Protein Lists: Accepts input lists of proteins specified by UniProt accession codes.
• Feature Allocation with Shapes and Colors: Assigns distinct shapes and colors to different features, which can be customized based on quantitative or qualitative data.
• Sorting by Homologous Features: Sorts proteins according to homologous feature content to facilitate classification of large protein families.
• Publication-Quality Output: Produces high-resolution maps suitable for publication.

Scientific Applications:

• Exploration of Protein Families: Enables exploration of large protein families to identify shared and divergent features.
• Insight into Feature Patterns: Aids identification of recurrent patterns or redundancies in protein feature architectures.
• Facilitation of Comparative Studies: Supports comparative analyses of feature architectures across proteins.

Methodology:

Users provide UniProt accession codes; annotated features are retrieved from UniProt and InterPro and rendered as customizable two-dimensional maps with shape and color encodings and optional sorting by homologous feature content.