ProFunc

ProFunc predicts protein function from known three-dimensional structures to identify functional motifs and relationships with characterized proteins.

Key Features:

• Structure Submission: Accepts protein coordinates in PDB format for downstream analysis.
• Comprehensive Analysis: Applies both established and innovative sequence- and structure-based methods to detect functional motifs and similarities to characterized proteins.
• Multi-faceted Methodology: Integrates multiple analytical techniques so complementary methods can provide convergent functional evidence.

Scientific Applications:

• Structural Genomics Annotation: Supports functional hypothesis generation for hypothetical proteins solved in structural genomics projects by providing sequence and structural evidence.
• Comparative Protein Analysis: Facilitates identification of conserved functional elements and evolutionary relationships within large protein families.

Methodology:

Accepts PDB-format coordinates and applies a range of sequence- and structure-based analytical techniques, combining established and novel methods to detect functional motifs and relationships.