ProKware

ProKware analyzes protein tertiary structures to identify domains, functional sites, post-translational modifications, and domain–domain interactions to provide structural and functional insights for molecular biology and bioinformatics.

Key Features:

• Comprehensive Structural Analysis: Enables exploration of detailed structural properties of proteins, including identification and visualization of domains, functional sites, and post-translational modifications.
• Three-dimensional Visualization: Provides dynamic manipulation and three-dimensional visualization of protein structures.
• Curated Protein Knowledge Database: Integrates a curated database to supply structural annotations and protein property information.
• Domain–Domain Interaction Analysis: Examines domain–domain interactions to clarify relationships between structural components within or between proteins.

Scientific Applications:

• Bioinformatics and Molecular Biology: Delivers detailed structural insights for studies on protein function, interactions, and the impacts of post-translational modifications.
• Drug Discovery: Supports identification of binding sites and active regions to inform structure-based drug discovery efforts.
• Evolutionary Biology: Facilitates domain analysis for assessing functional conservation and divergence across species.

Methodology:

Uses an integrated approach to present protein structural properties within tertiary structures and relies on a curated database for comprehensive structural annotations.