ProPan

ProPan profiles and analyzes prokaryotic pan-genome dynamics across 23 archaeal species and 1,481 bacterial species (51,882 strains) to support comparative genomics, taxonomy, pathogenicity, and environmental adaptation studies.

Key Features:

• Dataset scope: Contains pan-genome data spanning 23 archaeal species and 1,481 bacterial species representing 51,882 strains.
• Species composition and pan-genome evaluation: Evaluates species characteristics, composition, and evolutionary aspects within prokaryotic pan-genomes.
• Visualization and functional annotation: Maps associations, provides functional annotations, and displays presence/absence variation in gene clusters across species.
• Environmental adaptation insights: Predicts resistance genes to 126 substances, including biocides, antimicrobial drugs, and metals, and evaluates 31 metabolic cycle processes.

Scientific Applications:

• Pan-genome dynamics analysis: Comparative analysis of gene conservation, diversity, and pan-genome composition across prokaryotic species.
• Taxonomy and identification: Support for taxonomic profiling and species-level identification using pan-genome characteristics.
• Pathogenicity investigation: Assessment of gene presence/absence and functional annotations relevant to pathogenic traits.
• Environmental adaptation and resistance profiling: Identification of resistance determinants and metabolic traits associated with adaptation to environmental pressures.
• Metabolic pathway evaluation: Profiling of key metabolic cycle processes across species to study conservation and variation.

Methodology:

Prediction of resistance genes to 126 substances, evaluation of 31 metabolic cycle processes, mapping of gene-cluster presence/absence, and functional annotation and association mapping.