PROTAC-DB

PROTAC-DB curates and integrates structural, chemical, and experimental data for proteolysis-targeting chimeras (PROTACs) to support evaluation and rational design using degradation, binding, and cellular activity data.

Key Features:

• Extensive Data Integration: Integrates structural information and experimental data for 1662 PROTACs, including 202 warheads, 65 E3 ligands, and 806 linkers, and contains chemical structures, biological activities, and physicochemical properties.
• Detailed Experimental Data: Provides degradation capacities, binding affinities, and cellular activities for PROTACs to enable quantitative evaluation and comparison of compounds.
• Advanced Search Capabilities: Supports text-based searches (target name, compound name, or ID), structure-based searches, and filtering by physicochemical properties.

Scientific Applications:

• Rational Design of PROTACs: Facilitates design of new PROTAC molecules by providing integrated structural components and experimental activity data.
• Drug Discovery and Development: Enables identification and optimization of therapeutic PROTAC candidates using degradation and binding data relevant to ubiquitin-proteasome–mediated protein degradation.
• Educational Resource: Serves as a centralized repository of PROTAC chemical structures, experimental annotations, and physicochemical properties.

Methodology:

Integrates curated chemical structures, biological activities, and physicochemical properties for 1662 PROTACs and provides text-based searches (target name, compound name, or ID), structure-based searches, and filtering by physicochemical properties.