Protein Model Portal

Protein Model Portal provides unified access to experimental structures and theoretical three-dimensional molecular models to support integrated analysis of protein structural variability.

Key Features:

• Unified model repository: Provides unified access to experimental structures and theoretical three-dimensional molecular models, enabling combined analysis.
• Simultaneous search and analysis: Supports simultaneous searching and analysis of experimental and theoretical models.
• Consistent assessment and validation: Applies consistent assessment and validation criteria across all available structural models.
• Integration of modeling and quality-estimation servers: Integrates community-developed modeling servers for generating homology models and model quality estimation servers for validating structures.
• Continuous evaluation (CAMEO): Participating modeling servers are continuously evaluated through the Continuous Automated Model EvaluatiOn (CAMEO) project.
• Structural coverage mapping: Combines theoretical models with experimental structures to map structural coverage and support examination of structural variability.
• Association with Nature PSI: Operates as part of the Nature PSI Structural Biology Knowledgebase.

Scientific Applications:

• Model validation and benchmarking: Benchmark and validate homology and other computationally derived models using model quality estimation servers and CAMEO evaluations.
• Comparative structural analysis: Compare experimental and theoretical models to examine structural variability within proteins.
• Assessment of model utility: Assess model quality to determine the utility of models in research applications.
• Method development and benchmarking: Support evaluation and benchmarking of novel modeling servers and quality-estimation methods from the community.

Methodology:

Generation of homology models by modeling servers; validation of structures by model quality estimation servers; continuous automated evaluation of participating modeling servers via the Continuous Automated Model EvaluatiOn (CAMEO) project.