ProteomeExpert

ProteomeExpert performs analysis, modeling, visualization, and mining of large-scale quantitative proteomic datasets from mass spectrometry (including data-independent acquisition) and supports integration with omics derived from high-throughput sequencing, such as transcriptomics and metabolomics, to enable biomarker discovery and systems-level studies.


Key Features:

  • Web‑Server Deployment: Implemented in Docker and runnable within an R environment, enabling deployment on systems with Docker or R.
  • Comprehensive Analytical Tools: Provides experimental design, data mining, modeling, and interpretation capabilities tailored to quantitative proteomic datasets.
  • Omics Integration: Supports integration of proteomic data with transcriptomics and metabolomics for multi-omics analyses.
  • Visualization Capabilities: Offers advanced visualization options for complex quantitative proteomic data.

Scientific Applications:

  • Clinical Proteomics: Analysis of large-scale proteomic datasets for biomarker and therapeutic target identification.
  • Multi‑Omics Systems Biology: Integration of proteomic, transcriptomic, and metabolomic data for systems-level studies.
  • Experimental Design and Interpretation: Design and interpretation of quantitative proteomic experiments and complex datasets.

Methodology:

Computational functionality includes exploration, modeling, visualization, and mining of quantitative proteomic datasets, handling mass spectrometry data including data-independent acquisition, and integration with transcriptomics and metabolomics; the software is implemented in Docker and can run within an R environment.

Topics

Details

Tool Type:
web application
Programming Languages:
R
Added:
3/19/2021
Last Updated:
3/30/2021

Operations

Publications

Zhu T, Chen H, Yan X, Wu Z, Zhou X, Xiao Q, Ge W, Zhang Q, Xu C, Xu L, Ruan G, Xue Z, Yuan C, Chen G, Guo T. ProteomeExpert: a Docker image-based web server for exploring, modeling, visualizing and mining quantitative proteomic datasets. Bioinformatics. 2021;37(2):273-275. doi:10.1093/bioinformatics/btaa1088. PMID:33416829. PMCID:PMC8055226.

PMID: 33416829
Funding: - National Key R&D Program of China: 2020YFE0202200 - Zhejiang Provincial Natural Science Foundation for Distinguished Young Scholars: LR19C050001 - Hangzhou Agriculture and Society Advancement Program: 20190101A04 - National Natural Science Foundation of China: 81972492 - National Science Fund for Young Scholars: 21904107

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