Proteus

Proteus identifies stabilizing mutation pairs in target proteins by analyzing residue interactions from Protein Data Bank (PDB) structures to enhance protein stability and functionality.

Key Features:

• Mutation Pair Proposal: Identifies beneficial mutation pairs by converting non-interacting residues into interacting pairs within a target structure while preserving main-chain conformation and avoiding steric clashes.

Scientific Applications:

• Protein optimization for industrial biotechnology: Enhancing protein stability and function for applications including drug development, vaccine production, therapeutic treatments, food processing, and biofuel generation.

Methodology:

Transfers mutation pairs from known interacting residues in PDB structures to the target protein structure; effectiveness validated through case studies demonstrating inter-residue contact enhancement and consistency with experimental data.