protist.guru

protist.guru provides analysis of gene expression to construct and visualize co-expression and functional networks across 15 protist species to support investigation of gene function, metabolic pathways, and evolutionary relationships.

Key Features:

• Functional Co-Expression Networks: Construction and analysis of gene co-expression networks across multiple protist species to identify genes with correlated expression patterns.
• Gene Family Identification: Identification and grouping of gene families to explore evolutionary relationships and functional similarity among genes.
• Enriched Gene Cluster Analysis: Detection of enriched gene clusters that exhibit significant co-expression indicative of shared biological processes or pathways.
• Network Visualization and Analysis: Visualization and analytical tools for examining co-expression and functional networks.
• Expression Matrices and Sample Annotations: Integration and provision of expression matrices and sample annotations used for network and cluster analyses.

Scientific Applications:

• Metabolic pathway investigation: Exploration of pathways such as secondary carotenoid synthesis in Haematococcus lacustris to identify pathway-associated genes and regulatory patterns.
• Gene function and co-regulation inference: Identification of co-expressed genes to support hypotheses about gene function and regulatory interactions in protists.
• Microbial ecology and evolutionary biology: Comparative analysis across protist species to study ecological roles and evolutionary relationships of genes and pathways.

Methodology:

Analysis of gene expression data from 15 protist species using integrated expression matrices and sample annotations to construct co-expression networks, identify enriched gene clusters, and determine functional relationships among genes.