Protlego

Protlego automates design and structural evaluation of protein chimeras by recombining evolutionarily conserved protein fragments to investigate relationships between protein superfolds.

Key Features:

• Automated Chimera Design: Designs novel chimeric constructs by recombining evolutionarily conserved protein fragments into complex structures.
• High-Throughput Structural Analysis: Evaluates structural and energetic properties of designed and natural proteins using force fields Charmm and Amber.

Scientific Applications:

• Exploring Protein Superfolds: Facilitates construction and characterization of chimeric proteins to aid understanding of complex relationships between different superfolds.

Methodology:

Fragment retrieval from a database, network representation for recombination, structural modeling with force fields Charmm and Amber, and detailed analysis of structural features.