ProtView

ProtView generates in silico proteome digests and maps resulting peptides across protein, transcriptome, and genome references to identify and quantify evidence for transcriptional, co-transcriptional, post-transcriptional, and translational regulation.

Key Features:

• Comprehensive Digest Evaluation: Evaluates individual proteases and combinations, producing in silico digested peptides mapped to protein and genome references and identifying observable sections across the proteome, transcriptome, and genome.

Scientific Applications:

• Cancer Biology: Maps digested peptides across genomic references to study complex regulatory networks in cancer biology.
• Developmental Biology: Supports analysis of protein expression and regulation across proteome, transcriptome, and genome during development.
• Systems Biology: Enables evaluation of digest schemes and their observational coverage within systems biology studies.

Methodology:

Generates in silico proteome digests using various protease enzymes and maps resulting peptides to protein and genome databases.