Prrdb

Prrdb catalogs pattern recognition receptors (PRRs) and their ligands to support research on innate immune recognition and PAMP-triggered responses.

Key Features:

• Extensive Repository: Contains approximately 500 PRRs from 77 organisms, including 177 Toll-like receptors, 124 Scavenger receptors, and 67 Nucleotide Binding Site-Leucine Rich Repeat (NBS-LRR) receptors.
• Diverse Ligand Information: Catalogs 266 ligands encompassing carbohydrates, proteins, nucleic acids, glycolipids, glycoproteins, and lipopeptides representative of pathogen-associated molecular patterns (PAMPs).
• Integrated Web Tools: Provides search and browsing functions plus BLAST sequence comparison for pattern-recognition receptors.
• External Links: Cross-references entries to Swiss-Prot and PubMed.

Scientific Applications:

• Vaccine Development: Enables identification of PRR–PAMP interactions relevant for designing adjuvants for subunit vaccines.
• Immunological Research: Supports studies of innate immune recognition and signaling that influence adaptive immune responses.

Methodology:

Aggregates curated PRR and ligand data across multiple organisms and annotates receptor families; implements BLAST-based sequence comparison and cross-references to Swiss-Prot and PubMed.