PSIKO

PSIKO estimates individual ancestry coefficients and infers genome-wide ancestry to characterize population structure and control population stratification in genome-wide association studies (GWAS), and its extension psiko2 supports local ancestry inference for recent admixture.

Key Features:

• Ancestry Coefficient Estimation: Estimates individual ancestry coefficients from genomic data to quantify genetic composition of populations and inform evolutionary interpretations.
• Population Stratification Management: Accounts for population structure at various levels depending on the timing of admixture events to mitigate confounding in GWAS.
• Extension to Local Ancestry Inference: psiko2 extends genome-wide ancestry inference to local ancestry inference, enabling fine-scale analysis of small genomic segments in cases of recent admixture.

Scientific Applications:

• GWAS confounding control: Control for population stratification in genome-wide association studies to help identify true genetic associations with traits or diseases.
• Local ancestry analysis in recent admixture: Use psiko2 to perform local ancestry inference in studies involving recent admixture to account for fine-scale ancestry variation affecting genomic segments.

Methodology:

PSIKO employs advanced algorithms to analyze genomic data and estimate ancestry coefficients, is designed to handle complex population structures to provide genome-wide and local ancestry insights, and psiko2 incorporates techniques for fine-scale genetic analysis.