PSINDB

PSINDB catalogs human postsynaptic protein–protein interactions (PPIs) and their structural and experimental annotations to support analysis of synaptic molecular mechanisms.

Key Features:

• Comprehensive Data Collection: Aggregates tens of thousands of binding regions for postsynaptic proteins, combining experimental findings and computational predictions.
• Detailed Structural Information: Provides annotations of structural features that mediate and regulate PPI formation.
• Experimental Annotations: Associates each interaction with detailed experimental data and metadata.
• Support for Modeling and Analysis: Supplies interaction and structural data suitable for network and systems biology analyses.

Scientific Applications:

• Experiment design: Identifies candidate interactions and binding regions to guide biochemical and functional studies of postsynaptic proteins.
• Network and systems biology modeling: Enables construction and analysis of postsynaptic protein interaction networks to study system-level behavior.
• Molecular mechanism studies: Facilitates investigation of structural determinants of PPI formation and regulation in the postsynapse.
• Neurobiology of synaptic function: Supports research into synaptic function and processes related to learning and memory by providing postsynaptic interaction data.

Methodology:

Integrates experimental and computational evidence to aggregate binding regions and annotate interactions with structural features and experimental metadata.