PSSRdb

PSSRdb catalogs polymorphic simple sequence repeats (PSSRs) across 85 prokaryotic species to support analysis of SSR-mediated genetic variability and evolutionary adaptations.

Key Features:

• Relational database: catalogs polymorphic SSRs identified from comparative genomic analysis across 85 prokaryotic species.
• Genomic localization: provides the genomic positions of PSSRs and specifies regions that harbor these repeats.
• Length variation analysis: documents SSR length variations across different strains and isolates.
• Functional context: highlights PSSRs located near coding regions and their potential impacts on gene transcription and translation, including phase and antigenic variation.

Scientific Applications:

• Genomic research: supports exploration of genetic diversity and evolutionary mechanisms in prokaryotes.
• Pathogen study: facilitates investigation of bacterial pathogens where SSR-mediated phase and antigenic variations influence immune evasion.
• Comparative genomics: enables comparison of SSR patterns across strains and isolates to study adaptive consequences of SSR polymorphism.

Methodology:

Comparative analysis of genome sequences from multiple prokaryotic species was used to identify SSRs exhibiting length variations, which were systematically cataloged in the relational database.