pSTR Finder

pSTR Finder identifies polymorphic short tandem repeat (STR) loci by comparing two or more genomic sequences to enable genetic differentiation and forensic profiling.

Key Features:

• Identification of Polymorphic STR Loci: Identifies identical, polymorphic, and different STR loci by comparing two or more genomic sequences.
• Comprehensive Reporting: Generates detailed reports that list the number and genomic locations of identified STR loci to support analysis of complex mass genome sequences.
• Robustness to Fragmented Data: Consistently identifies STR loci in partial or fragmented DNA sequences, validated for forensic genetic analyses.

Scientific Applications:

• Forensic Genetics: Enables individual identification and genetic profiling by detecting polymorphic STR loci in whole-genome sequencing data.
• Marker Development and Population Studies: Supports development of genetic markers for legal investigations and population studies through comparative analysis of genomic sequences.

Methodology:

Analyzes genome sequences from databases such as GenBank; a proof-of-concept analysis of four human chromosome X samples reported 5,443 identical and 4,305 polymorphic STR loci using specific criteria for repeat units and flanking sequences.