pTARGET

pTARGET predicts the subcellular localization of proteins in non-plant eukaryotes across nine distinct subcellular locations to support genome-scale localization annotation.

Key Features:

• Prediction Basis: Uses occurrence patterns of location-specific protein functional domains and amino acid compositional differences to assign protein localization.
• High Accuracy and Performance: Achieves true positive rates of 68-87% with overall accuracy of 96-99% and outperforms PSORT by up to 60% in six of eight tested locations.
• Genome-Scale Prediction: Operates independently of signal or target peptides, enabling genome-scale predictions across diverse eukaryotic species.

Scientific Applications:

• Protein function and interaction studies: Provides subcellular localization predictions to support analysis of protein functions and interactions within cellular compartments.

Methodology:

Prediction is based on occurrence patterns of location-specific protein functional domains and amino acid compositional differences; the approach does not use signal or target peptides.